Myocardial Afterload Is a Key Biomechanical Regulator of Atrioventricular Myocyte Differentiation in Zebrafish

Heart valve development is governed by both genetic and biomechanical inputs.Prior work has demonstrated that oscillating shear stress associated with blood flow is required for normal atrioventricular (AV) valve development.Cardiac afterload is defined as the pressure the ventricle must overcome in order to pump blood throughout the circulatory sy

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Butyric Acid Added Apically to Intestinal Caco-2 Cells Elevates Hepatic ApoA-I Transcription and Rescues Lower ApoA-I Expression in Inflamed HepG2 Cells Co-Cultured in the Basolateral Compartment

Apolipoprotein A-I (ApoA-I) concentrations are decreased during inflammation, which may reduce high-density lipoprotein (HDL) functionality.Thus, rescuing ApoA-I concentrations during inflammation might help to prevent atherosclerosis.Recent studies have shown that butyric acid (C4) has anti-inflammatory effects and rescues ApoA-I production.Howeve

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Efficacy and safety of Naoxintong capsule for treating chronic stable angina: study protocol for a randomized controlled trial

Abstract Background Cardiovascular disease is the leading cause of mortality and morbidity worldwide, Chronic stable angina Pump Drive Belt (CSA) is the main symptom of myocardial ischemia, causes increased risk of major cardiovascular events such as sudden cardiac death and myocardial infarction.Naoxintong (NXT) capsule is a classical traditional

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